化工新型材料

化工新型材料 ›› 2021, Vol. 49 ›› Issue (3) : 173-176. DOI: 10.19817/j.cnki.issn 1006-3536.2021.03.039

科学研究

盐酸小檗碱/介孔二氧化硅载体的制备与缓释行为研究

作者信息 +

Investigation on preparation and sustained release behavior of BBH/mesoporous SiO₂ carrier

Lv Jiangwei¹, Wang Pengguang¹, Qu Youpeng², Zhang Wenjun¹, Wei Yaqing¹, Chen Wei¹

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文章历史 +

Received		Published
2019-11-09		2021-03-20
Issue Date	Revised Date
2021-05-10	2019-11-09

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摘要

采用水热合成法制备了SBA-15和SBA-16两种介孔SiO₂载体材料,利用浸渍法将盐酸小檗碱(BBH)原料药负载于载体上,制备了载药BBH/SBA-15和BBH/SBA-16。通过多种表征方法对载药后材料的晶体结构、孔道结构等进行了测试,并研究了材料的载药、释药规律。结果表明,SBA-15和SBA-16的载药量分别为13.50%和3.45%。与BBH原料药相比,两种介孔SiO₂载体均能够延长药物的释放,具有缓释效果。但SBA-15的孔径(5.77nm)较大,释药存在突释现象;而SBA-16的孔径(3.95nm)较小,能够缓慢释放药物。

Abstract

Two kinds of mesoporous silica(SiO₂) carriers,SBA-15 and SBA-16,were prepared by hydrothermal method,and berberine hydrochloride (BBH) as substance was loaded on the two carriers by dipping method to prepare BBH/SBA-15 and BBH/SBA-16.The crystal structure,pore structure of drug loaded mesoporous SiO₂ carriers were investigated by several tests.The drug loading and release mechanism of the carriers were also studied.The results showed that the drug loading of SBA-15 and SBA-16 were 13.50% and 3.45%,respectively.Compared with BBH,two kinds of SiO₂ carriers could extend the release of drugs,and had sustained release effect.The large pore size of SBA-15 (5.77nm) resulted in drug sudden release phenomenon,and the smaller pore size of SBA-16 (3.95nm) produced sustained release effect.

关键词

介孔二氧化硅 / 盐酸小檗碱 / SBA-16 / SBA-15 / 缓释

Key words

mesoporous silica / berberine hydrochloride / SBA-16 / SBA-15 / sustained release

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盐酸小檗碱/介孔二氧化硅载体的制备与缓释行为研究[J]. 化工新型材料, 2021, 49(3): 173-176 DOI:10.19817/j.cnki.issn 1006-3536.2021.03.039

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